Sergio Romero replaces David de Gea between the sticks whilst Phil Jones gets the nod in central defence after his performance against Arsenal.
Michael Carrick is also in midfield whilst Wayne Rooney has been recalled to the starting XI for the first time since his boozy hotel antics.
Zlatan Ibrahimovic returns to the line up after missing out at the weekend through suspension.
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Zlatan Ibrahimovic returns after suspensionGetty Images
After winning 11 of their first 12 games this season – one of which was against United – the Rotterdam side have had a rough few weeks, winning only one of their last five games, but will have been boosted ahead of their trip to Old Trafford by a 3-0 league win over PEC Zwolle at the weekend.
Mourinho's Manchester United have won both Europa League home fixtures so far this season, though, and should feel confident of completing the set.
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