Waddle was later seen exiting Neyland Stadium in an ambulance.
Alabama wide receiver Jaylen Waddle suffered an apparent ankle injury on the opening kickoff against Tennessee on Saturday afternoon.
While returning the kickoff, Waddle's foot got trapped as he was tackled near the sideline. His right ankle turned awkwardly and he could not put any weight on his leg as he made his way to Alabama's bench. Two Alabama medical staffers helped carry the junior toward the medical cart before he disappeared into the locker room. Waddle could be seen hitting the cart in frustration.
In the final seconds of the first quarter, the broadcast showed him exiting Neyland Stadium in an ambulance.
Redshirt-sophomore wide receiver Slade Bolden entered the game after Waddle exited the field.
CBS's Jamie Erdahl provided an update a few minutes after Waddle's departure, saying he was questionable to return to the game.
Waddle has been key to the success of Alabama's passing offense this season. Through four games, he has 25 catches for 557 yards and four touchdowns this season.