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Buffalo Bills vs. Indianapolis Colts NFL Week 11 Odds, Plays and Insights

Check out odds, plays and more for the Buffalo Bills vs. Indianapolis Colts NFL Week 11 matchup on November 21, 2021.

Buffalo Bills quarterback Josh Allen heads to the locker room after their win. The Buffalo Bills beat the New York Jets 45-17 at Metlife Stadium in East Rutherford, NJ on November 14, 2021. The Buffalo Bills Play The New York Jets At Metlife Stadium In East Rutherford Nj On November 14 2021

An NFL Week 11 matchup features the Buffalo Bills (6-3) playing the Indianapolis Colts (5-5).

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Odds for Bills vs. Colts

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Over/under insights

  • Buffalo has combined with its opponents to put up more than 50 points in four of nine games this season.
  • Indianapolis' games have gone over 50 points in four of 10 chances this season.
  • The two teams combine to average 57.9 points per game, 7.9 more than the total in this contest.
  • The 38 combined points per game that these two squads have allowed this season are 12.0 fewer than the 50 total in this contest.
  • The Bills and their opponents score an average of 49.3 points per game, 0.7 fewer than Sunday's total.
  • The 46.5 PPG average total in Colts games this season is 3.5 points fewer than this game's over/under.

Bills stats and trends

  • In Buffalo's nine games this year, it has six wins against the spread.
  • So far this season, the Bills have been installed as favorites by a 7.5-point margin or more five times and are 4-1 ATS in those contests.
  • Buffalo has eclipsed the over/under in 44.4% of its opportunities this year (four times in nine games with a set point total).
  • The Bills put up 31.1 points per game, 8.1 more than the Colts give up per contest (23.0).
  • Buffalo is 6-1 against the spread and 6-1 overall in games when it records more than 23.0 points.
  • The Bills average 37.5 more yards per game (401.1) than the Colts give up per contest (363.6).
  • In games that Buffalo picks up over 363.6 yards, the team is 4-2 against the spread and 4-2 overall.
  • The Bills have turned the ball over 10 times this season, 11 fewer than the Colts have forced (21).
  • Click over to SISportsbook and find the latest spread, moneyline and total for Buffalo's matchup with the Colts.

Colts stats and trends

  • Indianapolis has six wins against the spread in 10 games this year.
  • The Colts have been underdogs by 7.5 points or more once this year and covered the spread.
  • Indianapolis' games this season have hit the over six times in 10 opportunities (60%).
  • The Colts score 11.8 more points per game (26.8) than the Bills give up (15.0).
  • Indianapolis is 6-4 against the spread and 5-5 overall in games when it records more than 15.0 points.
  • The Colts rack up 363.4 yards per game, 89.3 more yards than the 274.1 the Bills give up.
  • When Indianapolis amasses more than 274.1 yards, the team is 6-3 against the spread and 5-4 overall.
  • This year the Colts have 10 turnovers, 14 fewer than the Bills have takeaways (24).

Home and road insights

  • At home this year, Buffalo is 3-1 against the spread and 3-1 overall.
  • At home, as 7.5-point favorites or more, the Bills are unbeaten ATS (3-0).
  • This season, in four home games, Buffalo has gone over the total once.
  • The average total in Bills home games this season is 47.3 points, 2.7 fewer than this matchup's over/under (50).
  • Indianapolis is 2-2 overall, and 3-1 against the spread, in away games.
  • This season, in three of four away games Indianapolis has gone over the total.
  • This season, Colts away games average 44.8 points, 5.2 fewer than this outing's over/under (50).

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