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Buffalo Bills vs. Indianapolis Colts NFL Week 11 Odds, Plays and Insights

Check out odds, plays and more for the Buffalo Bills vs. Indianapolis Colts NFL Week 11 matchup on November 21, 2021.

Buffalo Bills quarterback Josh Allen heads to the locker room after their win. The Buffalo Bills beat the New York Jets 45-17 at Metlife Stadium in East Rutherford, NJ on November 14, 2021. The Buffalo Bills Play The New York Jets At Metlife Stadium In East Rutherford Nj On November 14 2021

The Buffalo Bills (6-3) and Indianapolis Colts (5-5) will battle in a Week 11 NFL matchup.

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Odds for Bills vs. Colts

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Over/under insights

  • Buffalo has combined with its opponents to score more than 50 points in four of nine games this season.
  • So far this season, 40% of Indianapolis' games (4/10) have had more combined points than Sunday's over/under of 50.
  • Sunday's over/under is 7.9 points lower than the two team's combined 57.9 points per game average.
  • This contest's total is 12 points greater than the 38 these two squads combine to surrender per game this season.
  • Bills games have an average total of 49.3 points this season, 0.7 fewer than Sunday's over/under.
  • The 46.5 PPG average total in Colts games this season is 3.5 points fewer than this game's over/under.

Bills stats and trends

  • Buffalo has six wins against the spread in nine games this year.
  • The Bills are 4-1 ATS when favored by 7 points or more this season.
  • Buffalo's games this year have hit the over on four of nine set point totals (44.4%).
  • The Bills score 31.1 points per game, 8.1 more than the Colts give up per contest (23).
  • Buffalo is 6-1 against the spread and 6-1 overall in games when it records more than 23 points.
  • The Bills collect 37.5 more yards per game (401.1) than the Colts give up per contest (363.6).
  • Buffalo is 4-2 against the spread and 4-2 overall when the team piles up more than 363.6 yards.
  • The Bills have turned the ball over 10 times this season, 11 fewer than the Colts have forced (21).
  • Click over to SISportsbook and find the latest spread, moneyline and total for Buffalo's matchup with the Colts.

Colts stats and trends

  • Against the spread, Indianapolis is 6-4-0 this year.
  • The Colts have been underdogs by 7 points or more once this year and covered the spread.
  • Indianapolis' games this year have hit the over in 60% of its opportunities (six times in 10 games with a set point total).
  • The Colts score 11.8 more points per game (26.8) than the Bills surrender (15).
  • When Indianapolis scores more than 15 points, it is 6-4 against the spread and 5-5 overall.
  • The Colts rack up 89.3 more yards per game (363.4) than the Bills give up (274.1).
  • In games that Indianapolis picks up over 274.1 yards, the team is 6-3 against the spread and 5-4 overall.
  • The Colts have 10 giveaways this season, while the Bills have 24 takeaways.

Home and road insights

  • Buffalo is 3-1 against the spread, and 3-1 overall, at home this year.
  • This year, as 7-point favorites or more at home, the Bills are 3-0 ATS.
  • This year, in four home games, Buffalo has hit the over once.
  • Bills home games this season average 47.3 total points, 2.7 fewer than this contest's over/under (50).
  • In away games, Indianapolis is 3-1 against the spread, and 2-2 overall.
  • This year, in three of four away games Indianapolis has hit the over.
  • Colts away games this season average 44.8 total points, 5.2 fewer than this matchup's over/under (50).

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