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Buffalo Bills vs. Tennessee Titans NFL Week 6 Odds, Plays and Insights

Check out odds, plays and more for the Buffalo Bills vs. Tennessee Titans NFL Week 6 matchup on October 18, 2021.

Oct 3, 2021; Orchard Park, New York, USA; Buffalo Bills running back Devin Singletary (26) finds a hole to run against the Houston Texans in the fourth quarter at Highmark Stadium. Mandatory Credit: Mark Konezny-USA TODAY Sports

The top team in the AFC East, the Buffalo Bills (4-1), are 5.5-point favorites against the AFC South-leading Tennessee Titans (3-2) on Monday, October 18, 2021 at Nissan Stadium. A 54-point over/under is set for the contest.

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Odds for Bills vs. Titans

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Over/under insights

  • Buffalo and its opponents have combined to put up more than 54 points in three of six games this season.
  • Tennessee and its opponents have combined to score more than 54 points in two games this season.
  • The combined points per game average of the two teams, 60.8, is 6.8 points above Monday's over/under.
  • This contest's over/under is 15.2 points greater than the 38.8 these two squads combine to surrender per game this season.
  • The Bills and their opponents score an average of 49.0 points per game, 5.0 fewer than Monday's total.
  • The 49.6 PPG average total in Titans games this season is 4.4 points fewer than this game's over/under.

Bills stats and trends

  • Buffalo has five wins against the spread in five games this year.
  • This season, the Bills have two ATS wins in three games as a favorite of 5.5 points or more.
  • Buffalo's games this year have gone over the total in two out of six opportunities (33.3%).
  • The Bills rack up 34.4 points per game, 8.4 more than the Titans allow per contest (26).
  • When Buffalo records more than 26 points, it is 5-0 against the spread and 4-0 overall.
  • The Bills collect 33 more yards per game (410.4) than the Titans give up per matchup (377.4).
  • In games that Buffalo picks up over 377.4 yards, the team is 4-0 against the spread and 3-0 overall.
  • The Bills have four giveaways this season, while the Titans have four takeaways.
  • Click over to SISportsbook and find the latest spread, moneyline and total for Buffalo's matchup with the Titans.

Titans stats and trends

  • Tennessee has three wins against the spread in five games this season.
  • The Titans covered the spread in their only game when underdogs by 5.5 points or more.
  • Tennessee's games this season have hit the over on three of five set point totals (60%).
  • The Titans rack up 13.6 more points per game (26.4) than the Bills surrender (12.8).
  • Tennessee is 3-2 against the spread and 3-2 overall in games when it puts up more than 12.8 points.
  • The Titans rack up 137.4 more yards per game (389.2) than the Bills allow per matchup (251.8).
  • In games that Tennessee amasses more than 251.8 yards, the team is 3-1 against the spread and 3-1 overall.
  • The Titans have seven giveaways this season, while the Bills have 15 takeaways.

Home and road insights

  • Titans home games this season average 50.5 total points, 3.5 fewer than this matchup's over/under (54).
  • Buffalo is unbeaten against the spread, and 3-0 overall, in away games.
  • Buffalo has hit the over once in three away games this season.
  • Bills away games this season average 52.3 total points, 1.7 fewer than this outing's over/under (54).

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