Check out odds, insights and more in our betting preview for the Duke Blue Devils vs. Kansas Jayhawks college football matchup on September 25, 2021.

The Duke Blue Devils (2-1) are a heavy 15.5-point favorite heading into their matchup on Saturday, September 25, 2021 against the Kansas Jayhawks (1-2). The point total is set at 58 for the outing.
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Odds for Duke vs. Kansas
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Duke has combined with its opponents to score more than 58 points only twice this season.
- The two teams combine to average 49.6 points per game, 8.4 less than the over/under in this contest.
- These two squads surrender a combined 59.7 points per game, 1.7 more than this contest's over/under.
- The average total in Blue Devils games this season is 55.3, 2.7 points fewer than Saturday's over/under of 58 .
- The 58 total in this game is 7.5 points higher than the 50.5 average total in Jayhawks games this season.
Duke Stats and Trends
- Duke has two wins against the spread in three games this year.
- This season, the Blue Devils won ATS in their only game as a favorite of 15.5 points or more.
- Duke's games this year have gone over the point total two times in three opportunities (66.7%).
- This year, the Blue Devils rack up just 1.7 fewer points per game (34.3) than the Jayhawks allow (36.0).
- The Blue Devils collect 90.7 more yards per game (523.7) than the Jayhawks give up per matchup (433.0).
- In games that Duke amasses over 433.0 yards, the team is 1-1 against the spread and 1-1 overall.
- This year, the Blue Devils have turned the ball over five times, two more than the Jayhawks' takeaways (3).
- Find the latest spread and moneyline odds for Duke at SISportsbook.
Kansas Stats and Trends
- Kansas is winless against the spread this season.
- The Jayhawks have yet to cover the spread this season when underdogs by 15.5 points or more.
- The Jayhawks put up 15.3 points per game, 8.4 fewer than the Blue Devils allow (23.7).
- The Jayhawks collect 274.3 yards per game, 108.7 fewer yards than the 383.0 the Blue Devils give up.
- The Jayhawks have one giveaway this season, while the Blue Devils have five takeaways .
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.