Check out odds, insights and more in our betting preview for the Duke Blue Devils vs. Kansas Jayhawks college football matchup on September 25, 2021.

The Kansas Jayhawks (1-2) will look to prove oddsmakers wrong when they play the Duke Blue Devils (2-1) on Saturday, September 25, 2021 as a massive 16-point underdog. An over/under of 57 is set in the contest.
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Odds for Duke vs. Kansas
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Duke and its opponents have scored at least 57 points -- this matchup's over/under -- just two times this season.
- The combined points per game average of the two teams, 49.6, is 7.4 points fewer than Saturday's over/under.
- The 59.7 points per game these two squads have allowed to opponents this season are 2.7 more than the 57 over/under in this contest.
- Blue Devils games have an average total of 55.3 points this season, 1.7 fewer than Saturday's over/under.
- The 50.5 PPG average total in Jayhawks games this season is 6.5 points fewer than this game's over/under.
Duke Stats and Trends
- Duke has covered the spread two times this year.
- The Blue Devils covered the spread in their only game when favored by 16 points or more.
- Duke's games this year have gone over the point total two times in three opportunities (66.7%).
- This year, the Blue Devils put up just 1.7 fewer points per game (34.3) than the Jayhawks allow (36.0).
- The Blue Devils average 90.7 more yards per game (523.7) than the Jayhawks give up per matchup (433.0).
- When Duke totals over 433.0 yards, the team is 1-1 against the spread and 1-1 overall.
- The Blue Devils have turned the ball over five times this season, two more turnovers than the Jayhawks have forced (3).
- Find the latest spread and moneyline odds for Duke at SISportsbook.
Kansas Stats and Trends
- So far this year Kansas is winless against the spread.
- The Jayhawks have been underdogs by 16 points or more two times this season and have not covered the spread once.
- The Jayhawks rack up 8.4 fewer points per game (15.3) than the Blue Devils allow (23.7).
- The Jayhawks collect 108.7 fewer yards per game (274.3) than the Blue Devils give up (383.0).
- This season the Jayhawks have one turnover, four fewer than the Blue Devils have takeaways (5).
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.