Los Angeles Rams vs. San Francisco 49ers NFL Week 18 Odds, Plays and Insights


Check out odds, plays and more for the Los Angeles Rams vs. San Francisco 49ers NFL Week 18 matchup on January 9, 2022.

Sep 12, 2021; Detroit, Michigan, USA; San Francisco 49ers running back Elijah Mitchell (25) celebrates after scoring a touchdown during the second quarter against the Detroit Lions at Ford Field. Mandatory Credit: Raj Mehta-USA TODAY Sports

The Los Angeles Rams (12-4) will try to extend their five-game winning run in a Week 18 clash against the San Francisco 49ers (9-7).

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Odds for Rams vs. 49ers

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Over/under insights

  • Los Angeles has combined with its opponents to score more than 44.5 points in 10 of 16 games this season.
  • In 56.2% of San Francisco's games this season (9/16), the teams combined to score more than Sunday's over/under of 44.5.
  • Sunday's total is 7.8 points lower than the two team's combined 52.3 points per game average.
  • This contest's total is 1.6 points greater than the 42.9 these two squads combine to allow per game this season.
  • The Rams and their opponents have scored an average of 49.7 points per game in 2021, 5.2 more than Sunday's total.
  • In 2021, games involving the 49ers have averaged a total of 46.9 points, 2.4 more than the set over/under in this contest.

Rams stats and trends

  • Los Angeles is 8-8-0 against the spread this season.
  • So far this season, the Rams have been installed as favorites by a 3.5-point margin or more 11 times and are 4-7 ATS in those contests.
  • Los Angeles has hit the over in 50% of its opportunities this year (eight times over 16 games with a set point total).
  • This year, the Rams average 6.0 more points per game (27.3) than the 49ers allow (21.3).
  • When Los Angeles puts up more than 21.3 points, it is 7-4 against the spread and 10-1 overall.
  • The Rams collect 378.8 yards per game, 66.0 more yards than the 312.8 the 49ers give up per contest.
  • When Los Angeles totals more than 312.8 yards, the team is 8-7 against the spread and 12-3 overall.
  • This year, the Rams have turned the ball over 21 times, three more than the 49ers' takeaways (18).
  • Click over to SISportsbook and find the latest spread, moneyline and total for Los Angeles' matchup with the 49ers.

49ers stats and trends

  • San Francisco has eight wins against the spread in 16 games this year.
  • The 49ers have covered the spread once this year when underdogs by 3.5 points or more (in two chances).
  • San Francisco has eclipsed the over/under in 43.8% of its opportunities this year (seven times in 16 games with a set point total).
  • The 49ers average 25.0 points per game, 3.4 more than the Rams give up (21.6).
  • When San Francisco records more than 21.6 points, it is 7-3 against the spread and 8-2 overall.
  • The 49ers rack up 32.7 more yards per game (371.1) than the Rams allow per outing (338.4).
  • San Francisco is 5-4 against the spread and 6-3 overall when the team churns out more than 338.4 yards.
  • The 49ers have 22 giveaways this season, while the Rams have 23 takeaways.

Home and road insights

  • At home this season, Los Angeles is 5-2 overall and 4-3 against the spread.
  • This season, as 3.5-point favorites or greater at home, the Rams are 3-3 ATS.
  • In three of seven home games this year, Los Angeles has gone over the total.
  • This season, Rams home games average 50.6 points, 6.1 more than this outing's over/under (44.5).
  • This year away from home, San Francisco is 4-4 against the spread and 5-3 overall.
  • The 49ers have two wins ATS (2-2) as 3.5-point underdogs or more on the road.
  • This season, in three of eight away games San Francisco has gone over the total.
  • The average point total in 49ers away games this season is 46.1 points, 1.6 more than this outing's over/under (44.5).

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