Check out odds, insights and more in our betting preview for the Louisville Cardinals vs. Florida State Seminoles college football matchup on September 25, 2021.

Oddsmakers project a tight contest when the Louisville Cardinals (2-1, 0-0 ACC) visit the Florida State Seminoles (0-3, 0-0 ACC) on Saturday, September 25, 2021 in a matchup between ACC opponents at Bobby Bowden Field at Doak Campbell Stadium. Louisville is favored by 1.5 points. The contest has a 61.5-point over/under.
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Odds for Louisville vs. Florida State
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Florida State has combined with its opponents to score more than 61.5 points in one game this season.
- The combined points per game average of the two teams, 55, is 6.5 points fewer than Saturday's over/under.
- This contest's over/under is 2.5 points above the 59 these two squads combine to surrender per game this season.
- Cardinals games this season feature an average total of 64.8 points, a number 3.3 points higher than Saturday's over/under.
- In 2021, games involving the Seminoles have averaged a total of 58.5 points, 3.0 fewer than this game's set over/under.
Louisville Stats and Trends
- Louisville has covered the spread on one occasion this season.
- This season, the Cardinals are winless against the spread when entering a game as a favorite of 1.5 points or more.
- The Cardinals score the same number of points per game that the Seminoles allow (32.0).
- The Cardinals average only 10.6 more yards per game (432.3) than the Seminoles allow per matchup (421.7).
- When Louisville churns out over 421.7 yards, the team is 1-1 against the spread and 2-0 overall.
- This year, the Cardinals have turned the ball over four times, while the Seminoles have forced four.
- Find the latest spread and moneyline odds for Louisville at SISportsbook.
Florida State Stats and Trends
- So far this year Florida State has one win against the spread.
- This year, the Seminoles have one ATS win in two games as an underdog of 1.5 points or more.
- Florida State's games this season have gone over the point total one time in three opportunities (33.3%).
- The Seminoles score 23.0 points per game, 4.0 fewer than the Cardinals give up (27.0).
- The Seminoles rack up 42.0 fewer yards per game (364.7) than the Cardinals give up (406.7).
- The Seminoles have turned the ball over six more times (10 total) than the Cardinals have forced a turnover (4) this season.
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.