Check out odds, insights and more in our betting preview for the Michigan State Spartans vs. Nebraska Cornhuskers college football matchup on September 25, 2021.

The Nebraska Cornhuskers (2-2, 0-0 Big Ten) are 5-point underdogs in a road conference matchup against the No. 20 Michigan State Spartans (3-0, 0-0 Big Ten) on Saturday, September 25, 2021 at Spartan Stadium. A 52-point over/under is set for the game.
For more great betting and fantasy insight, join the SI Winners Club Newsletter.
Odds for Michigan State vs. Nebraska
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Michigan State has combined with its opponents to put up more than 52 points in all three games this season.
- Nebraska's games have gone over 52 points in just one opportunity this season.
- The combined points per game average of the two teams, 68.8, is 16.8 points more than Saturday's over/under.
- These two squads combine to surrender 33.1 points per game, 18.9 fewer than this contest's over/under.
- The Spartans and their opponents score an average of 51.5 points per game, 0.5 fewer than Saturday's total.
- The 57.3 PPG average total in Cornhuskers games this season is 5.3 points more than this game's over/under.
Michigan State Stats and Trends
- Michigan State has covered the spread twice this season.
- The Spartans have been favored by 5 points or more one time this season and have not covered the spread in any of them.
- Michigan State's games this year have hit the over on two of three set point totals (66.7%).
- This year, the Spartans put up 23.5 more points per game (39.3) than the Cornhuskers surrender (15.8).
- Michigan State is 2-0-1 against the spread and 3-0 overall this season when the team records more than 15.8 points.
- The Spartans collect 173.7 more yards per game (520.0) than the Cornhuskers allow per outing (346.3).
- When Michigan State piles up more than 346.3 yards, the team is 2-0-1 against the spread and 3-0 overall.
- This year, the Spartans have two turnovers, three fewer than the Cornhuskers have takeaways (5).
- Find the latest spread and moneyline odds for Michigan State at SISportsbook.
Nebraska Stats and Trends
- Thus far this season Nebraska has two wins against the spread.
- The Cornhuskers have been underdogs by 5 points or more once this year and covered the spread.
- Nebraska's games this year have not eclipsed the over/under yet in three opportunities.
- This season the Cornhuskers rack up 12.2 more points per game (29.5) than the Spartans allow (17.3).
- When Nebraska records more than 17.3 points, it is 1-1 against the spread and 2-1 overall.
- The Cornhuskers rack up 100.0 more yards per game (481.3) than the Spartans allow (381.3).
- In games that Nebraska picks up more than 381.3 yards, the team is 2-1 against the spread and 2-2 overall.
- This year the Cornhuskers have turned the ball over five times, while the Spartans have forced 5 turnovers.
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.