Saturday's matchup was the final game on both Ohio State and Michigan's regular-season schedules.
Saturday's rivalry game between Michigan and Ohio State has been canceled due to an increasing number of COVID-19 cases and athletes in quarantine within the Wolverines' program.
"The number of positive tests has continued to trend in an upward direction over the last seven days," Warde Manuel, Michigan's athletic director, said in a statement. "We have not been cleared to participate in practice at this time. Unfortunately, we will not be able to field a team."
The school said it will continue daily testing in hopes it can return to practice soon.
Saturday's matchup was the final game on both Ohio State and Michigan's regular-season schedules.
The Buckeyes are 5–0 and projected to represent the Big Ten East in the conference's championship game on Dec. 19. Under Big Ten rules, teams must play six regular-season games to qualify for the title game. The Buckeyes have already missed two games this season, so the conference will either have to change the rule or find Ohio State another opponent to play in order to qualify.
Concerns about a possible cancellation of Saturday's game first appeared last week when Michigan was forced to cancel its game against Maryland due to a COVID-19 outbreak.