Check out odds, insights and more in our betting preview for the Oklahoma State Cowboys vs. Kansas State Wildcats college football matchup on September 25, 2021.

The Oklahoma State Cowboys (3-0, 0-0 Big 12) are 6-point favorites when they host the No. 25 Kansas State Wildcats (3-0, 0-0 Big 12) in a Big 12 matchup on Saturday, September 25, 2021 at Boone Pickens Stadium. The point total is set at 46.5.
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Odds for Oklahoma State vs. Kansas State
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Kansas State's games have gone over 46.5 points in two opportunities this season.
- The two teams combine to score 55 points per game, 8.5 more than the over/under in this contest.
- This contest's total is 11.1 points more than the 35.4 these two squads combine to allow per game this season.
- The Cowboys and their opponents have scored an average of 54.3 points per game in 2021, 7.8 more than Saturday's total.
- The 53.0 PPG average total in Wildcats games this season is 6.5 points more than this game's over/under.
Oklahoma State Stats and Trends
- Thus far this season Oklahoma State has one win against the spread.
- This season, the Cowboys are winless ATS when entering a game as a favorite of 6 points or more.
- The Cowboys score 8.3 more points per game (24.0) than the Wildcats give up (15.7).
- Oklahoma State is 1-1 against the spread and 3-0 overall this season when the team puts up more than 15.7 points.
- The Cowboys rack up 56.7 more yards per game (336.7) than the Wildcats allow per matchup (280.0).
- In games that Oklahoma State picks up over 280.0 yards, the team is 1-1 against the spread and 3-0 overall.
- This year, the Cowboys have five turnovers, one fewer than the Wildcats have takeaways (6).
- Find the latest spread and moneyline odds for Oklahoma State at SISportsbook.
Kansas State Stats and Trends
- Kansas State has covered the spread on two occasions this season.
- Kansas State's games this season have eclipsed the over/under one time in three opportunities (33.3%).
- The Wildcats put up 11.3 more points per game (31.0) than the Cowboys allow (19.7).
- Kansas State is 2-1 against the spread and 3-0 overall in games when it puts up more than 19.7 points.
- The Wildcats rack up 374.0 yards per game, 45.3 more yards than the 328.7 the Cowboys allow.
- In games that Kansas State piles up more than 328.7 yards, the team is 2-1 against the spread and 3-0 overall.
- The Wildcats have turned the ball over five times this season, one more turnover than the Cowboys have forced (4).
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.