Check out odds, insights and more in our betting preview for the Penn State Nittany Lions vs. Villanova Wildcats college football matchup on September 25, 2021.

The No. 6 Penn State Nittany Lions (3-0) host the FCS Villanova Wildcats on Saturday, September 25, 2021 at Beaver Stadium. The Nittany Lions are heavily favored by 29 points in the contest.
For more great betting and fantasy insight, join the SI Winners Club Newsletter.
Odds for Penn State vs. Villanova
Odds courtesy of SI Sportsbook.
Penn State Stats and Trends
- Against the spread, Penn State is 3-0-0 this year.
- Penn State's games this year have yet to go over the total in three opportunities.
- The Nittany Lions rack up 18.3 more points per game (29.3) than the Wildcats surrender (11).
- When Penn State records more than 11 points, it is 3-0 against the spread and 3-0 overall.
- The Nittany Lions collect 395.3 yards per game, 210.6 more yards than the 184.7 the Wildcats allow per contest.
- When Penn State picks up over 184.7 yards, the team is 3-0 against the spread and 3-0 overall.
- The Nittany Lions have turned the ball over one time this season, one more turnover than the Wildcats have forced (0).
- Find the latest spread and moneyline odds for Penn State at SISportsbook.
Villanova Stats and Trends
- So far this season Villanova has one win against the spread.
- The Wildcats score 31.0 more points per game (45.3) than the Nittany Lions give up (14.3).
- Villanova is 1-1 against the spread and 3-0 overall when the team notches more than 14.3 points.
- The Wildcats collect 112.4 more yards per game (454.7) than the Nittany Lions allow (342.3).
- The Wildcats have turned the ball over zero times, six fewer times than the Nittany Lions have forced turnovers (6).
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.