The clubs are level on points (3) in the Champions League after both beat Istanbul Basaksehir 2-0.
It's only been 78 days since RB Leipzig and PSG met in the semifinal of last season's UEFA Champions League, with PSG prevailing decisively.
Both clubs clubs are eager to find a victory after a bumpy start to the 2020-21 campaign. RB Leipzig fell to Manchester United 5-0 this season, the club's all-time worst European defeat and the heaviest ever in the Champions League group stage by a German team since 2014, when Schalke 04 lost 5-0 to Chelsea.
PSG also lost to Manchester United. The English side leads the group with two wins in two matches entering Wednesday.
Coming into the match at Red Bull Arena Leipzig, PSG has won nine of its last 14 away UEFA Champions League group stage competitions and is unbeaten in the club's last six.
For Leipzig, winning this match is crucial in order to progress to the knockout stages for a second successive season. The clubs are level on points in the Champions League after both beat Istanbul Basaksehir 2-0.
News broke on Tuesday that PSG would be without Kylian Mbappe due to a thigh injury. Forwards Neymar (hamstring) and Mauro Icardi (knee) are already on the sidelines. Five other players are also out on Wednesday.
As for Leipzig, they too are missing key players. Marcel Halstenberg (muscular), Fabrice Hartmann (knee), Lucas Klostermann (knee) and Konrad Laimer (ankle) are all ruled out for the match-up.
How to Watch:
Time: 3 p.m. ET
TV Channel: TUDNxtra
Live Stream: You can stream the match on Fubo TV. Sign up now for a seven-day free trial. You can also watch on CBS All Access.