Check out odds, plays and more for the San Francisco 49ers vs. Green Bay Packers NFL Week 3 matchup on September 26, 2021.

The Green Bay Packers (1-1) are 3.5-point underdogs heading into their matchup on Sunday, September 26, 2021 against the San Francisco 49ers (2-0). The game's point total is 50.
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Odds for 49ers vs. Packers
Odds courtesy of SI Sportsbook.
Over/under insights
- San Francisco played five games with more than 50 points scored, its current matchup's total, last year.
- Last season, 13 of Green Bay's 18 games had a combined total of more than 50 points scored.
- These teams averaged a combined 55.3 points per game a season ago, 5.3 more points than the over/under of 50 set for this matchup.
- Opponents of these two teams averaged a combined 47.5 points per game last season, 2.5 fewer than the point total in this game.
- The 49ers' average point total in matchups last year was 47.1, 2.9 points below the over/under in this game.
- The average point total for the Packers in 2020 was 0.8 points higher than this game's over/under.
49ers stats and trends
- San Francisco went 7-9-0 ATS last season.
- The 49ers covered the spread once when favored by 3.5 points or more last season (in five opportunities).
- San Francisco's games went over the point total eight out of 16 times last season.
- The 49ers averaged just 0.4 more points per game (23.5) than the Packers surrendered (23.1) last year.
- San Francisco was 4-3 against the spread and 4-3 overall last season when the team recorded more than 23.1 points.
- The 49ers racked up 36.1 more yards per game (370.1) than the Packers allowed per outing (334) last year.
- San Francisco was 6-7 against the spread and 6-7 overall when the team totaled more than 334 yards last season.
- The 49ers turned the ball over 13 more times (31 total) than the Packers forced a turnover (18) last year.
- Click over to SISportsbook and find the latest odds on this matchup.
Packers stats and trends
- Green Bay compiled a 10-6-0 record against the spread last year.
- The Packers covered the spread when playing as at least 3.5-point underdogs in their only opportunity last year.
- In Green Bay's games last year, the combined scoring went over the point total nine times.
- The Packers scored 7.4 more points per game (31.8) than the 49ers gave up (24.4) last year.
- Green Bay was 11-3 against the spread and 12-2 overall last season when the team notched over 24.4 points.
- The Packers collected 74.6 more yards per game (389) than the 49ers allowed per contest (314.4) last season.
- When Green Bay picked up over 314.4 yards last season, the team was 11-5 against the spread and 13-3 overall.
- Last year the Packers had 11 turnovers, nine fewer than the 49ers had takeaways (20).
Home and road insights
- San Francisco covered the spread twice at home, and was 1-7 overall there, last year.
- At home last year, the 49ers were winless ATS (0-3) as 3.5-point favorites or greater.
- Last year, in eight home games, San Francisco went over the total four times.
- The average total in 49ers home games last season was 47.6 points, 2.4 fewer than this contest's over/under (50).
- Last season away from home, Green Bay was 5-3 against the spread and 6-2 overall.
- The Packers had two wins ATS (2-1) away from home as 3.5-point underdogs or more.
- Last year, in eight away games, Green Bay hit the over five times.
- Last season, Packers away games averaged 51.4 points, 1.4 more than this contest's over/under (50).
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