San Francisco 49ers vs. Tennessee Titans NFL Week 16 Odds, Plays and Insights

Dec 23, 2021

Check out odds, plays and more for the San Francisco 49ers vs. Tennessee Titans NFL Week 16 matchup on December 23, 2021.

The San Francisco 49ers (8-6) will clash with the Tennessee Titans (9-5) in Week 16 of the NFL season.

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Odds for 49ers vs. Titans

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San Francisco's games this season have gone over 44.5 points nine of 14 times.
Tennessee has combined with its opponents to score more than 44.5 points in seven of 14 games this season.
The combined points per game average of the two teams, 49.8, is 5.3 points greater than Thursday's over/under.
This contest's total is equal to the 44.5 points per game these two squads have combined to surrender this season.
The 49ers and their opponents have scored an average of 47.2 points per game in 2021, 2.7 more than Thursday's total.
The 44.5-point over/under for this game is 4.2 points below the 48.7 points per game average total in Titans games this season.

San Francisco has played 14 games, with seven wins against the spread.
This season, the 49ers have an against the spread record of 4-4 in their eight games as a favorite of 3.5 points or more.
San Francisco's games this year have hit the over on seven of 14 set point totals (50%).
This year, the 49ers put up 3.6 more points per game (25.7) than the Titans give up (22.1).
San Francisco is 6-3 against the spread and 7-2 overall this season when the team records more than 22.1 points.
The 49ers average 37.4 more yards per game (366.6) than the Titans allow per outing (329.2).
In games that San Francisco picks up more than 329.2 yards, the team is 6-5 against the spread and 7-4 overall.
The 49ers have turned the ball over 19 times this season, one more turnover than the Titans have forced (18).
Click over to SISportsbook and find the latest spread, moneyline and total for San Francisco's matchup with the Titans.

Tennessee has played 14 games, with eight wins against the spread.
So far this year, the Titans have been installed as underdogs by a 3.5-point margin or more five times and are 4-1 ATS in those contests.
Tennessee has eclipsed the over/under in 50% of its opportunities this season (seven times in 14 games with a set point total).
The Titans average just 1.7 more points per game (24.1) than the 49ers allow (22.4).
Tennessee is 7-2 against the spread and 8-1 overall when the team puts up more than 22.4 points.
The Titans average 23.3 more yards per game (345.1) than the 49ers give up per outing (321.8).
Tennessee is 6-3 against the spread and 6-3 overall when the team piles up over 321.8 yards.
The Titans have turned the ball over eight more times (25 total) than the 49ers have forced a turnover (17) this season.

Tennessee is 4-3 against the spread, and 5-2 overall, at home.
At home, the Titans have two wins ATS (2-1) as 3.5-point underdogs or greater.
Tennessee has hit the over twice in seven home games this year.
The average point total in Titans home games this season is 49.1 points, 4.6 more than this contest's over/under (44.5).
Away from home, San Francisco is 5-2 overall and 4-3 against the spread.
Away from home, the 49ers have two wins ATS (2-1) as 3.5-point favorites or more.
San Francisco has gone over the total in three of seven road games this season.
This season, 49ers away games average 46.1 points, 1.6 more than this outing's over/under (44.5).