Sportsbooks are incredibly accurate with their projections, so you can use that to your advantage in fantasy.
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San Francisco's loss to Indianapolis on Sunday Night Football marked the 49ers' fourth consecutive defeat.
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Saquon Barkley will miss his second straight game and the Giants once again dominate the injury report
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The injury report for Sunday is long and filled with top-tier talent. See which players are active, questionable and out here.
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Trey Lance is San Francisco's new signal caller after Jimmy Garoppolo exited Sunday's contest with a calf injury.
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