The Colts are 1-4 against the spread in their last five games as favorites.
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The 49ers are small road favorites in Week 8 against the Rams. San Francisco is going for the season sweep.
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The Cowboys are large favorites at home in Week 8 against the Bears.
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The Patriots are slight road favorites against the Jets in Week 8 as they aim to defeat their rivals for a 13th straight time.
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The undefeated Eagles are the biggest favorites in Week 8 as they spot 11 points to the Steelers.
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