Check out odds, insights and more in our betting preview for the TCU Horned Frogs vs. SMU Mustangs college football matchup on September 25, 2021.

The TCU Horned Frogs (2-0) and the SMU Mustangs (3-0) take the field to try to take home the Iron Skillet on Saturday, September 25, 2021 at Amon G. Carter Stadium. The Horned Frogs are double-digit, 10-point favorites. The over/under is set at 64.
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Odds for TCU vs. SMU
Odds courtesy of SI Sportsbook.
Over/Under Insights
- The two teams combine to average 82.8 points per game, 18.8 more than the over/under in this contest.
- These two squads combine to allow 36.8 points per game, 27.2 fewer than this contest's over/under.
- The average total in Horned Frogs games this season is 46.5, 17.5 points fewer than Saturday's total of 64 .
- The 70.3 PPG average total in Mustangs games this season is 6.3 points more than this game's over/under.
TCU Stats and Trends
- The Horned Frogs have been favored by 10 points or more one time this season and have not covered the spread in any of them.
- The Horned Frogs put up 39.5 points per game, 20.2 more than the Mustangs allow per contest (19.3).
- TCU is 0-1 against the spread and 2-0 overall in games when it records more than 19.3 points.
- The Horned Frogs collect 24.2 more yards per game (464.5) than the Mustangs give up per contest (440.3).
- The Horned Frogs have two giveaways this season, while the Mustangs have seven takeaways .
- Find the latest spread and moneyline odds for TCU at SISportsbook.
SMU Stats and Trends
- SMU has covered the spread once this year.
- This season the Mustangs put up 25.8 more points per game (43.3) than the Horned Frogs give up (17.5).
- SMU is 1-1 against the spread and 3-0 overall when the team records more than 17.5 points.
- The Mustangs collect 245.2 more yards per game (534.7) than the Horned Frogs allow per matchup (289.5).
- In games that SMU piles up over 289.5 yards, the team is 1-1 against the spread and 3-0 overall.
- The Mustangs have turned the ball over four times this season, two more turnovers than the Horned Frogs have forced (2).
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.