Check out odds, plays and more for the Tennessee Titans vs. Indianapolis Colts NFL Week 3 matchup on September 26, 2021.

The Indianapolis Colts (0-2) are 5.5-point underdogs in a road AFC South matchup with the Tennessee Titans (1-1) on Sunday, September 26, 2021 at Nissan Stadium. The over/under is 48 for this game.
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Odds for Titans vs. Colts
Odds courtesy of SI Sportsbook.
Over/under insights
- Tennessee played 13 games with more than 48 points scored, its current matchup's over/under, last season.
- Last year, nine of Indianapolis' 17 games had a combined total higher than 48 points scored.
- The Titans and the Colts combined to average 10.9 more points per game a season ago than the over/under of 48 set for this game.
- Opponents of these two teams averaged a combined 50 points per game last season, two more than the point total for this game.
- The average total the Titans had set in matchups last year was 2.3 more points than this outing's point total.
- Colts games in 2020 averaged a total that is the same as the point total in this matchup.
Titans stats and trends
- Tennessee won seven games against the spread last season, while failing to cover nine times.
- The Titans had an ATS record of 3-3 when playing as at least 5.5-point favorites last season.
- Tennessee's games hit the over 12 out of 16 times last season.
- The Titans put up 8.1 more points per game (30.7) than the Colts gave up (22.6) last year.
- When Tennessee scored over 22.6 points last season, it was 7-5 against the spread and 10-2 overall.
- The Titans collected 64.3 more yards per game (396.4) than the Colts gave up per contest (332.1) last season.
- In games that Tennessee amassed more than 332.1 yards last year, the team was 6-6 against the spread and 10-2 overall.
- The Titans turned the ball over 12 times last year, 13 fewer than the Colts forced turnovers (25).
- Click over to SISportsbook and get the latest odds on this matchup.
Colts stats and trends
- Indianapolis won eight games against the spread last season, while failing to cover eight times.
- The Colts covered the spread when playing as at least 5.5-point underdogs in their only opportunity last year.
- Indianapolis' games hit the over nine out of 16 times last season.
- The Colts put up just 0.8 more points per game (28.2) than the Titans allowed (27.4) last season.
- When Indianapolis recorded more than 27.4 points last year, it was 6-2 against the spread and 8-0 overall.
- The Colts racked up 20.2 fewer yards per game (378.1) than the Titans gave up (398.3) per matchup last season.
- Indianapolis was 4-3 against the spread and 5-2 overall when the team piled up more than 398.3 yards last year.
- The Colts had 15 giveaways last year, while the Titans had 23 takeaways.
Home and road insights
- Tennessee was 4-4 against the spread, and 5-3 overall, at home last year.
- At home last year, the Titans had two wins ATS (2-1) as 5.5-point favorites or greater.
- Last year, Tennessee went over the total in six of eight home games.
- Titans home games last season averaged 50.3 total points, 2.3 more than this outing's over/under (48).
- Indianapolis was 5-3 against the spread, and 5-3 overall, on the road last season.
- Away from home, the Colts were winless ATS (0-1) as 5.5-point underdogs or more.
- Last season, in six of eight away games Indianapolis went over the total.
- Last season, Colts away games averaged 47.4 points, 0.6 fewer than this outing's over/under (48).
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